![]() If the slide continues to fail, a note accompanies the case in our LIS indicating that the glass slide needs to be viewed by the pathologist. In cases of failure to scan the entire tissue area or weak staining intensity, an attempt to rescan the slide is made. Slides that do not pass these metrics typically result from a failure to scan the entire tissue area on slide, weak H&E or immunohistochemical staining intensity, or incorrect slide labels. The average pass rate for our daily quality metrics is 97.43% (2083 of 2138). Currently, we prospectively scan on average 2138 slides each day in conjunction with daily quality assurance metrics: H&E and immunohistochemical staining intensity, scanning of entire tissue area, and slide labels. As of September 2020, we have scanned and archived approximately 1.7 million slides from more than 190 000 clinical cases. In December 2019, we built our new histology laboratory with 6 Philips UFSs installed adjacent to the histology staining machines, which significantly improved our DP workflow ( Figure 1). The validation study established diagnostic concordance between digital WSIs and glass slides for the same observer, which ranged from 91% to 100% (average, 95%). 14 The validation process included a sample set of 60 surgical pathology cases with H&E-stained, formalin-fixed, paraffin-embedded tissue slides that reflected the spectrum and complexity of specimen types and diagnoses likely to be encountered during our routine practice 20 cases of immunohistochemical stained slides and 20 cases of special stained slides (Grocott-Gomori methenamine silver stain, acid-fast bacillus stain, etc). Shortly after, we validated this system in house for clinical diagnostic purposes in accordance with the College of American Pathologists guideline. FMT0145 with software version 1.8, and Philips display PP27 QHD Royal Philips, Amsterdam, Netherlands). In 2017 the US Food and Drug Administration approved the first pixel pipeline for primary diagnosis, the Philips DP system ( Table 1), consisting of Philips IntelliSite Pathology Solution 3.2 systems (IMS software version 3.2.1, Ultra Fast Scanner serial No. ![]()
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